Elisabetta Ciani Selected Research

CDKL5 deficiency disorder

5/2021	Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder.
5/2020	Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons.
1/2020	Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder.
1/2019	Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist.
1/2018	CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder.
1/2018	Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder.
1/2018	Treatment with the GSK3-beta inhibitor Tideglusib improves hippocampal development and memory performance in juvenile, but not adult, Cdkl5 knockout mice.
1/2017	CDKL5 deficiency entails sleep apneas in mice.

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Elisabetta Ciani Research Topics

Disease

16	Down Syndrome (Down's Syndrome) 01/2020 - 04/2006
9	Intellectual Disability (Idiocy) 05/2020 - 11/2012
8	Neurodevelopmental Disorders 05/2021 - 01/2014
8	CDKL5 deficiency disorder 05/2021 - 01/2017
5	Neuroblastoma 05/2020 - 12/2002
4	Seizures (Absence Seizure) 05/2021 - 10/2014
4	Brain Diseases (Brain Disorder) 05/2020 - 01/2014
4	Rett Syndrome (Rett's Disorder) 01/2017 - 01/2014
3	Epilepsy (Aura) 05/2020 - 01/2018
2	Vision Disorders (Hemeralopia) 05/2021 - 01/2018
2	Alzheimer Disease (Alzheimer's Disease) 10/2015 - 02/2015
2	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2008 - 04/2006
1	Olfaction Disorders (Cacosmia) 01/2017
1	Sleep Apnea Syndromes (Sleep Apnea) 01/2017
1	Cognitive Dysfunction 02/2015
1	Trisomy (Trisomies) 01/2015
1	Dementia (Dementias) 02/2008
1	Prodromal Symptoms 02/2008
1	Disease Progression 04/2006
1	Neoplasms (Cancer) 05/2003

Drug/Important Bio-Agent (IBA)

10	Cyclin-Dependent Kinases (cdk Proteins)IBA 05/2021 - 01/2014
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2003
4	Amyloid (Amyloid Fibrils)IBA 01/2020 - 04/2006
4	Fluoxetine (Prozac)FDA LinkGeneric 02/2015 - 01/2013
2	Biomarkers (Surrogate Marker)IBA 05/2020 - 01/2017
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 12/2002
2	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 01/2020 - 12/2002
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 07/2017 - 10/2015
2	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2017 - 10/2016
2	LithiumIBA 01/2017 - 01/2010
2	Pharmaceutical PreparationsIBA 02/2014 - 03/2013
2	Choline O-Acetyltransferase (Choline Acetyltransferase)IBA 02/2008 - 04/2006
1	bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA 05/2020
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 05/2020
1	Sertraline (Zoloft)FDA LinkGeneric 01/2020
1	Transcription Factors (Transcription Factor)IBA 11/2012
1	Acetylcholine (Acetylcholine Chloride)FDA Link 02/2008
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 02/2008
1	Cholinergic Agents (Cholinergics)IBA 02/2008
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 09/2004
1	Nitric Oxide Synthase (NO Synthase)IBA 09/2004

Therapy/Procedure

7	Therapeutics 05/2021 - 02/2008
7	Drug Therapy (Chemotherapy) 01/2020 - 06/2010